saikosaponin A, saikosaponin B, saikosaponin B1, saikosaponin B2, saikosaponin B3, saikosaponin B4, saikosaponin C, saikosaponin D, saikosaponin K, saikosaponin L, saikosaponins
Name | Saikosaponin A | ||
PubChem CID | 167928 | ||
Molecular Weight | 781.0g/mol | ||
Synonyms |
saikosaponin A, saikosaponin B, saikosaponin B1, saikosaponin B2, saikosaponin B3, saikosaponin B4, saikosaponin C, saikosaponin D, saikosaponin K, saikosaponin L, saikosaponins |
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Formula | C₄₂H₆₈O₁₃ | ||
SMILES | CC1C(C(C(C(O1)OC2CCC3(C(C2(C)CO)CCC4(C3C=CC56C4(CC(C7(C5CC(CC7)(C)C)CO6)O)C)C)C)O)OC8C(C(C(C(O8)CO)O)O)O)O | ||
InChI | 1S/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3/t21-,22-,23-,24-,25-,26+,27+,28+,29-,30+,31-,32-,33+,34+,35+,37+,38+,39-,40+,41-,42+/m1/s1 | ||
InChIKey | KYWSCMDFVARMPN-MSSMMRRTSA-N | ||
CAS Number | 20736-09-8 | ||
ChEMBL ID | CHEMBL3542194 | ||
ChEBI ID | CHEBI:8996 | ||
KEGG ID | C08975 | ||
Structure |
Download
2D
MOL
3D
MOL
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Chineses Pinyin | ChaiHu | ||
Use Part | Root | ||
Habitat | HuBei, SiChuan, AnHui | ||
Flavor | Pungent, Bitter | ||
Meridian Tropism | Liver, Gallbladder, Lung | ||
Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Apiaceae
-->Genus: Bupleurum
-->Species: Bupleurum scorzonerifolium
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Chineses Pinyin | HongChaiHu | ||
Use Part | Root | ||
Habitat | HeiLongJiang, JiLin, LiaoNing, HeBei, ShanDong, ShanXi, Shaanxi, JiangSu, AnHui, GuangXi, NeiMengGu, GanSu | ||
Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Apiales
-->Family: Apiaceae
-->Genus: Bupleurum
-->Species: Bupleurum scorzonerifolium
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Pair Name | Saikosaponin A, Docetaxel | |||
Partner Name | Docetaxel | |||
Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
Biological Phenomena | Induction-->Autophagy | |||
Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
Down-regulation | Expression | MAP1LC3A | hsa84557 | |
Up-regulation | Expression | MAP1LC3B | hsa81631 | |
Down-regulation | Expression | SQSTM1 | hsa8878 | |
In Vitro Model | LNCaP | Prostate carcinoma | Homo sapiens (Human) | CVCL_0395 |
PC-3 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0035 | |
DU145 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0105 | |
L-02 | Papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_6926 | |
HEK293T | Healthy | Homo sapiens (Human) | CVCL_0063 | |
WPMY-1 | Healthy | Homo sapiens (Human) | CVCL_3814 | |
In Vivo Model | PC-3 cells (2×10⁶) were injected subcutaneously into the right flank of each mouse. | |||
Result | SSA is posed as a novel QCCs-eradicating agent by aggravating autophagy in QCCs. In combination with the current therapy, SSA has potential to improve treatment effectiveness and to prevent cancer recurrence. |