InterPAD - DETAILS

saikosaponin A, saikosaponin B, saikosaponin B1, saikosaponin B2, saikosaponin B3, saikosaponin B4, saikosaponin C, saikosaponin D, saikosaponin K, saikosaponin L, saikosaponins

No.	Title	Href
1	Saikosaponin A enhances Docetaxel efficacy by selectively inducing death of dormant prostate cancer cells through excessive autophagy. Cancer Lett. 2023 Feb 1;554:216011. doi: 10.1016/j.canlet.2022.216011.	`Click`

No.

Title

Href

Saikosaponin A enhances Docetaxel efficacy by selectively inducing death of dormant prostate cancer cells through excessive autophagy. Cancer Lett. 2023 Feb 1;554:216011. doi: 10.1016/j.canlet.2022.216011.

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Name	Saikosaponin A
PubChem CID	167928
Molecular Weight	781.0g/mol
Synonyms	saikosaponin A, saikosaponin B, saikosaponin B1, saikosaponin B2, saikosaponin B3, saikosaponin B4, saikosaponin C, saikosaponin D, saikosaponin K, saikosaponin L, saikosaponins
Formula	C₄₂H₆₈O₁₃
SMILES	CC1C(C(C(C(O1)OC2CCC3(C(C2(C)CO)CCC4(C3C=CC56C4(CC(C7(C5CC(CC7)(C)C)CO6)O)C)C)C)O)OC8C(C(C(C(O8)CO)O)O)O)O
InChI	1S/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3/t21-,22-,23-,24-,25-,26+,27+,28+,29-,30+,31-,32-,33+,34+,35+,37+,38+,39-,40+,41-,42+/m1/s1
InChIKey	KYWSCMDFVARMPN-MSSMMRRTSA-N
CAS Number	20736-09-8
ChEMBL ID	CHEMBL3542194
ChEBI ID	CHEBI:8996
KEGG ID	C08975
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	ChaiHu
Use Part	Root
Habitat	HuBei, SiChuan, AnHui
Flavor	Pungent, Bitter
Meridian Tropism	Liver, Gallbladder, Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Bupleurum 　　　　　　-->Species: Bupleurum scorzonerifolium

Chineses Pinyin	HongChaiHu
Use Part	Root
Habitat	HeiLongJiang, JiLin, LiaoNing, HeBei, ShanDong, ShanXi, Shaanxi, JiangSu, AnHui, GuangXi, NeiMengGu, GanSu
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Bupleurum 　　　　　　-->Species: Bupleurum scorzonerifolium

Pair Name	Saikosaponin A, Docetaxel
Partner Name	Docetaxel
Disease Info	[ICD-11: 2C82.0]	Prostate cancer		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Expression	AKT1	hsa207
	Down-regulation	Expression	SQSTM1	hsa8878
	Down-regulation	Expression	MAP1LC3A	hsa84557
	Up-regulation	Expression	MAP1LC3B	hsa81631
In Vitro Model	LNCaP	Prostate carcinoma	Homo sapiens (Human)	CVCL_0395
	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
	DU145	Prostate carcinoma	Homo sapiens (Human)	CVCL_0105
	L-02	Papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_6926
	HEK293T	Healthy	Homo sapiens (Human)	CVCL_0063
	WPMY-1	Healthy	Homo sapiens (Human)	CVCL_3814
In Vivo Model	PC-3 cells (2×10⁶) were injected subcutaneously into the right flank of each mouse.
Result	SSA is posed as a novel QCCs-eradicating agent by aggravating autophagy in QCCs. In combination with the current therapy, SSA has potential to improve treatment effectiveness and to prevent cancer recurrence.